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PDE1B is the isoform with the highest expression levels in the striatum and cortex, and its ability to hydrolyze cAMP (Km: 12 M) and cGMP (Km: 1.2 M) has made it a research hot spot for schizophrenia (Goraya and Cooper, 2005)
Yes GHK-Cu is one of the more frequently studied compounds in dermatological wrinkle-reduction research
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